MOTS-C
For laboratory research use only — not for human or animal consumption.
Research-grade MOTS-c, a 16-amino acid mitochondrial-derived peptide encoded in the 12S rRNA region of mtDNA, ≥99% HPLC purity with third-party batch-level Certificate of Analysis. For laboratory research use only.
Description
MOTS-c
MOTS-c is a 16-amino acid mitochondrial-derived peptide. Preclinical research explores its roles in metabolic regulation, insulin sensitivity, and exercise-mimetic effects.
Key Research Areas
- • Studied for regulation of metabolic homeostasis through AMPK activation and modulation of energy expenditure.
- • Investigated for enhancement of insulin sensitivity and glucose/lipid metabolism in obesity and diabetes models.
- • Explored for exercise-mimetic effects and protection against age-related metabolic decline in various research paradigms.
Product Specifications
| Product | MOTS-c |
| CAS Number | Research peptide (mitochondrial-derived) |
| Molecular Formula | C101H152N28O22S2 |
| Molar Mass | 2174.6 g/mol |
| Sequence | MRWQEMGYIFYPRKLR |
| Synonyms | MOTS-c; Mitochondrial ORF of the 12S rRNA-c |
| Purity | ≥99% (HPLC) |
| Form | Lyophilized powder |
| Storage | −20°C (−4°F) long-term; 2–8°C (36–46°F) reconstituted |
| Solubility | Bacteriostatic water for laboratory use |
Mechanism of Action
MOTS-c is a 16-amino acid peptide encoded within the mitochondrial 12S rRNA gene. In cell and mouse studies it has been reported to inhibit the folate–methionine cycle, raise AICAR levels, and activate AMP-activated protein kinase (AMPK), with downstream effects on glucose utilization and skeletal-muscle metabolism. Under metabolic stress MOTS-c has been observed to translocate to the nucleus and regulate nuclear gene expression, and exercise-training studies in mice associate MOTS-c with PGC-1α-dependent mitochondrial adaptation. Observations summarized here derive from in vitro assays and animal models; the material sold on this page has not been evaluated in controlled human trials.
Research Literature
- • Lee et al. (2015) — the mitochondrial-derived peptide MOTS-c and metabolic homeostasis in mouse models. PMID: 25738459.
- • Kim et al. (2018) — MOTS-c nuclear translocation and gene regulation under metabolic stress. PMID: 29983246.
- • Yang et al. (2021) — MOTS-c with exercise intervention and AMPK signaling in mice. PMID: 33722744.
- • Additional peer-reviewed literature is indexed on PubMed under the compound name.
Reconstitution & Storage
Lyophilized MOTS-c is stable at −20°C or colder in its sealed vial; −80°C is preferable for long-term archival. Reconstitute in bacteriostatic water (0.9% benzyl alcohol) to a laboratory working concentration of 1–5 mg/mL for in vitro use. Once reconstituted, refrigerate at 2–8°C and use within approximately 30 days. Aliquot into single-use vials at reconstitution to avoid repeated freeze-thaw cycles of the working solution. Every batch ships with a third-party Certificate of Analysis; request the analytical file for your batch at /coa.
Research Use Only
For research use only. Not intended for human or veterinary consumption, therapeutic use, dietary supplementation, cosmetic use, or clinical application. Not FDA-approved. Purchasers confirm the material will be used solely for in vitro laboratory research and not administered to humans or animals.
