TB-500
For laboratory research use only — not for human or animal consumption.
Research-grade TB-500, a synthetic peptide fragment of thymosin beta-4 spanning its actin-binding domain, ≥99% HPLC purity with third-party batch-level Certificate of Analysis. For laboratory research use only.
Description
TB-500
TB-500 is a synthetic fragment of thymosin beta-4 corresponding to its actin-binding domain. Preclinical research explores its roles in cell migration, actin regulation, and tissue repair processes.
TB-500: This is a shorter, man-made chain of only 7 amino acids. It is produced synthetically to retain the actin-binding motif of thymosin beta-4 that has been studied in preclinical tissue-repair models.
TB4 Thymosin Beta-4 is a naturally occurring 43-amino acid peptide that serves as the primary actin-sequestering protein in most mammalian cells. Preclinical research in animal and in vitro models investigates its involvement in cell migration, wound repair mechanisms, and tissue regeneration processes.
Key Research Areas
- • Studied for regulation of actin dynamics and facilitation of cell migration and motility during tissue repair.
- • Investigated for acceleration of wound healing and regenerative processes in dermal, muscle, corneal, and other tissue models.
- • Explored for anti-inflammatory and protective effects in various injury, fibrosis, and inflammatory research models.
Product Specifications
| Product | TB-500 |
| CAS Number | 885340-08-9 |
| Molecular Formula | C38H68N10O14 |
| Molar Mass | 889.02 g/mol |
| Sequence | Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln |
| Synonyms | TB-500; Thymosin Beta-4 fragment; Ac-LKKTETQ |
| Purity | ≥99% (HPLC) |
| Form | Lyophilized powder |
| Storage | −20°C (−4°F) long-term; 2–8°C (36–46°F) reconstituted |
| Solubility | Bacteriostatic water for laboratory use |
Mechanism of Action
Thymosin beta-4 (Tβ4) is a 43-amino acid G-actin-sequestering peptide; TB-500 corresponds to its central actin-binding motif (LKKTETQ). In cultured cells and rodent models Tβ4 has been reported to regulate actin polymerization, promote cell migration, and modulate inflammatory signaling, effects that have been studied in dermal, corneal, and cardiac injury models. Observations summarized here derive from in vitro assays and animal models; the material sold on this page has not been evaluated in controlled human trials.
Research Literature
- • Goldstein et al. (2005) — thymosin beta4 as an actin-sequestering protein studied in tissue-injury models. PMID: 16099219.
- • Philp & Kleinman (2010) — animal studies with thymosin beta4 across tissue-repair and regeneration models. PMID: 20536453.
- • Kim et al. (2017) — thymosin β4 in a dermal burn-wound model via actin cytoskeletal remodelling and HSP70. PMID: 25921810.
- • Additional peer-reviewed literature is indexed on PubMed under the compound name.
Reconstitution & Storage
Lyophilized TB-500 is stable at −20°C or colder in its sealed vial; −80°C is preferable for long-term archival. Reconstitute in bacteriostatic water (0.9% benzyl alcohol) to a laboratory working concentration of 1–5 mg/mL for in vitro use. Once reconstituted, refrigerate at 2–8°C and use within approximately 30 days. Aliquot into single-use vials at reconstitution to avoid repeated freeze-thaw cycles of the working solution. Every batch ships with a third-party Certificate of Analysis; request the analytical file for your batch at /coa.
Research Use Only
For research use only. Not intended for human or veterinary consumption, therapeutic use, dietary supplementation, cosmetic use, or clinical application. Not FDA-approved. Purchasers confirm the material will be used solely for in vitro laboratory research and not administered to humans or animals.