Sermorelin
For laboratory research use only — not for human or animal consumption.
Research-grade sermorelin (GHRH 1-29 NH2), a 29-amino acid growth hormone-releasing hormone analog, ≥99% HPLC purity with third-party batch-level Certificate of Analysis. For laboratory research use only.
Description
Sermorelin
Sermorelin is a synthetic 29-amino acid analog of growth hormone-releasing hormone (GHRH). Preclinical studies investigate its stimulation of growth hormone secretion in laboratory models.
Key Research Areas
- • Studied for GHRH-mediated GH and IGF-1 elevation in research models.
- • Investigated for effects on pulsatile GH release patterns in laboratory settings.
- • Explored for modulation of growth hormone axis signaling in preclinical metabolic research.
Product Specifications
| Product | Sermorelin |
| CAS Number | 86168-78-7 |
| Molecular Formula | C149H246N44O42S |
| Molar Mass | ~3358 g/mol |
| Sequence | Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2 |
| Synonyms | Sermorelin; GHRH (1-29) |
| Purity | ≥99% (HPLC) |
| Form | Lyophilized powder |
| Storage | −20°C (−4°F) long-term; 2–8°C (36–46°F) reconstituted |
| Solubility | Bacteriostatic water for laboratory use |
Mechanism of Action
Sermorelin is the 1–29 amino-acid N-terminal fragment of human growth hormone-releasing hormone (GHRH), amidated at the C-terminus, and is the shortest GHRH sequence retaining full receptor activity in structure–activity studies. It binds the GHRH receptor on anterior-pituitary somatotrophs, raising intracellular cAMP and stimulating pulsatile growth-hormone release in a physiologically regulated manner that remains subject to somatostatin feedback in animal models. Observations summarized here derive from in vitro assays and animal models; the material sold on this page has not been evaluated in controlled human trials.
Research Literature
- • Cervini et al. (1998) — systematic structure–activity relationship studies of hGHRH(1-29)-NH2. PMID: 9513600.
- • Barabutis (2020) — review of growth hormone-releasing hormone biology. PMID: 32289177.
- • Additional peer-reviewed literature is indexed on PubMed under the compound name.
Reconstitution & Storage
Lyophilized sermorelin is stable at −20°C or colder in its sealed vial; −80°C is preferable for long-term archival. Reconstitute in bacteriostatic water (0.9% benzyl alcohol) to a laboratory working concentration of 1–5 mg/mL for in vitro use. Once reconstituted, refrigerate at 2–8°C and use within approximately 30 days. Aliquot into single-use vials at reconstitution to avoid repeated freeze-thaw cycles of the working solution. Every batch ships with a third-party Certificate of Analysis; request the analytical file for your batch at /coa.
Research Use Only
For research use only. Not intended for human or veterinary consumption, therapeutic use, dietary supplementation, cosmetic use, or clinical application. Not FDA-approved. Purchasers confirm the material will be used solely for in vitro laboratory research and not administered to humans or animals.
