PT-141
For laboratory research use only — not for human or animal consumption.
Research-grade PT-141 (bremelanotide), a cyclic heptapeptide melanocortin MC3R/MC4R agonist, ≥99% HPLC purity with third-party batch-level Certificate of Analysis. For laboratory research use only.
Description
PT-141
PT-141 (bremelanotide) is a synthetic cyclic heptapeptide and selective melanocortin receptor agonist. Preclinical research examines its activity at central melanocortin (MC3R/MC4R) pathways in rodent behavioral models.
Key Research Areas
- • Studied as a potent melanocortin receptor agonist (primarily MC3R and MC4R) in rodent models of sexual behavior.
- • Investigated for central nervous system modulation of sexual behavior and motivational pathways in preclinical models.
- • Explored for potential roles in energy balance and metabolic regulation via melanocortin signaling.
Product Specifications
| Product | PT-141 |
| CAS Number | 189691-06-3 |
| Molecular Formula | C50H68N14O10 |
| Molar Mass | ~1025 g/mol |
| Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH |
| Synonyms | PT-141; Bremelanotide |
| Purity | ≥99% (HPLC) |
| Form | Lyophilized powder |
| Storage | −20°C (−4°F) long-term; 2–8°C (36–46°F) reconstituted |
| Solubility | Bacteriostatic water for laboratory use |
Mechanism of Action
PT-141 (bremelanotide) is a cyclic heptapeptide analog of α-melanocyte-stimulating hormone that acts as an agonist at melanocortin receptors, with highest reported affinity for MC4R and MC3R and, unlike its parent Melanotan II, no significant activity at MC1R-mediated pigmentation in the models studied. Its behavioral effects in rodents are attributed to central (hypothalamic) melanocortin signaling rather than peripheral vascular action, and MC4R structural studies have characterized the ligand-binding pocket it engages. Observations summarized here derive from in vitro assays and animal models; the material sold on this page has not been evaluated in controlled human trials.
Research Literature
- • Molinoff et al. (2003) — PT-141 pharmacology as a melanocortin agonist. PMID: 12851303.
- • Pfaus et al. (2004) — melanocortin receptor agonist effects on solicitation behavior in the female rat. PMID: 15226502.
- • Zhang et al. (2021) — structural insights into ligand recognition and activation of the melanocortin-4 receptor. PMID: 34433901.
- • Additional peer-reviewed literature is indexed on PubMed under the compound name.
Reconstitution & Storage
Lyophilized PT-141 is stable at −20°C or colder in its sealed vial; −80°C is preferable for long-term archival. Reconstitute in bacteriostatic water (0.9% benzyl alcohol) to a laboratory working concentration of 1–5 mg/mL for in vitro use. Once reconstituted, refrigerate at 2–8°C and use within approximately 30 days. Aliquot into single-use vials at reconstitution to avoid repeated freeze-thaw cycles of the working solution. Every batch ships with a third-party Certificate of Analysis; request the analytical file for your batch at /coa.
Research Use Only
For research use only. Not intended for human or veterinary consumption, therapeutic use, dietary supplementation, cosmetic use, or clinical application. Not FDA-approved. Purchasers confirm the material will be used solely for in vitro laboratory research and not administered to humans or animals.