Pinealon
Pinealon is a synthetic tripeptide (Glu-Asp-Arg) developed as a bioregulator derived from pineal gland research. Preclinical studies in cell cultures and animal models indicate that Pinealon may support neuronal function, modulate pineal gland activity, and exhibit neuroprotective and anti-aging effects through regulation of gene expression and cellular metabolism.[1][2]
Key Research Areas
- Neuroprotection & Brain Cell Function – In vitro neuronal cultures and rodent models of stress or aging show Pinealon protects neurons from oxidative damage, improves cell viability, and normalizes metabolic processes in brain tissue.[3][4]
- Pineal Gland & Circadian Regulation – Preclinical investigations in aged animals demonstrate Pinealon modulates melatonin synthesis, supports pinealocyte activity, and helps restore age-related declines in pineal function.[5][6]
- Anti-Aging & Gene Expression Modulation – Animal studies suggest Pinealon influences expression of genes related to cellular repair, antioxidant defense, and longevity pathways in brain and other tissues.[7][8]
Product Specifications
| CAS Number |
135736-50-6 |
| Molecular Formula |
C17H29N7O9 |
| Molar Mass |
475.44 g/mol |
| Sequence |
Glu-Asp-Arg |
| Synonyms |
Pinealon tripeptide, Glu-Asp-Arg, Pineal gland bioregulator |
| Purity |
≥99% (HPLC) |
| Form |
Lyophilized powder |
| Storage |
−20°C (long-term), 2–8°C (reconstituted) |
| Solubility |
Bacteriostatic water or sterile saline for reconstitution |
References
- 1. Khavinson VK, et al. Pinealon increases cell viability in neuronal cultures under oxidative stress. Bull Exp Biol Med. 2005. PubMed
- 2. Khavinson VK, et al. Effect of synthetic peptides on pineal gland function in aging. Adv Gerontol. 2003. (Pineal regulation data)
- 3. Arushanian EB, et al. Pinealon normalizes disturbed circadian rhythms in aged rats. Bull Exp Biol Med. 2006. PubMed
- 4. Khavinson VK, et al. Pinealon protects neurons in models of brain ischemia. Neurochem Res. 2008. (Neuroprotection context)
- 5. Khavinson VK, et al. Bioregulatory effects of short peptides on pineal gland in aging. Adv Gerontol. 2007. PubMed
- 6. Khavinson VK, et al. Epitalon and Pinealon in regulation of pineal melatonin synthesis. Bull Exp Biol Med. 2004. (Related pineal studies)
- 7. Khavinson VK, et al. Geroprotective effect of Pinealon in animal models of aging. Adv Gerontol. 2010. PubMed
- 8. Khavinson VK, et al. Short peptides in regulation of gene expression and cellular functions. Bull Exp Biol Med. 2009. PubMed
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