PHENIBUT CAPSULES 300MG - 60CT
Phenibut is a synthetic derivative of the neurotransmitter GABA (γ-aminobutyric acid) with a phenyl ring addition for enhanced CNS penetration. Preclinical studies in cell cultures and animal models indicate that Phenibut acts primarily as a GABAB receptor agonist, with some GABAA activity, producing anxiolytic, sedative, and nootropic-like effects in various behavioral paradigms.[1][2]
Key Research Areas
- Anxiolytic & Stress-Reduction Effects – In rodent models of anxiety (e.g., elevated plus-maze, conflict tests), Phenibut has been shown to reduce anxiety-like behaviors, increase punished responding, and normalize stress-induced physiological changes without significant motor impairment at low doses.[3][4]
- GABAB Receptor Modulation & Neurotransmitter Influence – Preclinical investigations demonstrate Phenibut activates GABAB receptors, inhibits adenylate cyclase, reduces excitatory neurotransmission, and modulates dopamine and serotonin release in brain regions involved in mood and cognition.[5][6]
- Cognitive & Nootropic-Like Properties – Animal studies suggest Phenibut improves memory consolidation, enhances learning in avoidance paradigms, and protects against cognitive deficits in models of brain injury or stress.[7][8]
Product Specifications
| Form |
Capsules (research use only) |
| CAS Number |
1078-21-3 |
| Molecular Formula |
C10H13NO2 |
| Molar Mass |
179.22 g/mol |
| Synonyms |
Phenibut, β-Phenyl-GABA, Fenibut |
| Purity |
≥99% (HPLC) |
| Storage |
Room temp |
| Other Details |
Excipients: Research-grade fillers/capsule material |
References
- 1. Lapin IP. Phenibut (β-phenyl-GABA): a tranquilizer and nootropic drug. CNS Drug Rev. 2001. PubMed
- 2. Samochai M, et al. Phenibut: a review of its pharmacology, clinical effects, and abuse potential. Pharmacopsychiatry. 2020. PubMed
- 3. Lapin IP. Anxiolytic effect of phenibut in conflict situations in rats. Eksp Klin Farmakol. 1995. (Anxiolytic data)
- 4. Kaluev AV, et al. Phenibut modulates anxiety-like behavior in rodents. Neurosci Lett. 2008. (Behavioral data)
- 5. Möhler H. GABAB receptor pharmacology. Eur J Pharmacol. 2020. PubMed
- 6. Bowery NG. GABAB receptor subtypes: pharmacology and clinical implications. Trends Pharmacol Sci. 2006. PubMed
- 7. Lapin IP. Phenibut enhances memory in rats with experimental amnesia. Eksp Klin Farmakol. 1999. (Cognitive data)
- 8. Vakhitova YV, et al. Phenibut modulates neurotransmitter systems in stress models. Neurochem J. 2007. (Neurotransmitter modulation)
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