GLUTATHIONE 1500MG
Glutathione (GSH; γ-L-Glutamyl-L-cysteinyl-glycine) is a naturally occurring tripeptide composed of glutamate, cysteine, and glycine. It functions as a major endogenous antioxidant in cells. Preclinical studies in cell cultures and animal models demonstrate that Glutathione scavenges reactive oxygen species, supports detoxification processes, maintains redox homeostasis, and protects against oxidative damage in various experimental systems.[1][2]
Key Research Areas
- Antioxidant Defense & Oxidative Stress Protection – In vitro cell models and rodent studies show Glutathione directly neutralizes free radicals, regenerates other antioxidants (e.g., vitamins C and E), and prevents lipid peroxidation under oxidative challenge.[3][4]
- Detoxification & Xenobiotic Metabolism – Preclinical investigations indicate Glutathione conjugates with electrophilic compounds via glutathione S-transferases (GSTs), facilitating excretion and reducing cellular toxicity in models of chemical exposure.[5][6]
- Cellular Protection in Disease Models – Animal models of inflammation, ischemia, and neurodegeneration suggest Glutathione supplementation or modulation reduces tissue damage, supports mitochondrial function, and modulates inflammatory pathways.[7][8]
Product Specifications
| CAS Number |
70-18-8 |
| Molecular Formula |
C10H17N3O6S |
| Molar Mass |
307.32 g/mol |
| Sequence |
γ-Glu-Cys-Gly |
| Synonyms |
GSH, Reduced Glutathione, γ-L-Glutamyl-L-cysteinyl-glycine |
| Purity |
≥99% (HPLC) |
| Form |
Lyophilized powder |
| Storage |
−20°C (long-term), 2–8°C (reconstituted) |
| Solubility |
Bacteriostatic water or sterile saline for reconstitution |
References
- 1. Pompella A, et al. The changing faces of glutathione, a cellular protagonist. Biochem Pharmacol. 2003. PubMed
- 2. Forman HJ, et al. Glutathione: overview of its protective roles, measurement, and biosynthesis. Mol Aspects Med. 2009. PubMed
- 3. Lu SC. Glutathione synthesis. Biochim Biophys Acta. 2013. PubMed
- 4. Meister A. Glutathione metabolism and its selective modification. J Biol Chem. 1988. PubMed
- 5. Hayes JD, et al. Glutathione transferases. Annu Rev Pharmacol Toxicol. 2005. PubMed
- 6. Townsend DM, et al. The importance of glutathione in human disease. Biomed Pharmacother. 2003. PubMed
- 7. Wu G, et al. Glutathione metabolism and its implications for health. J Nutr. 2004. PubMed
- 8. Sies H. Glutathione and its role in cellular functions. Free Radic Biol Med. 1999. PubMed
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