BPC-157 + TB-500 + GHK-Cu : GLOW
BPC-157 + TB-500 + GHK-Cu blend is a research peptide combination consisting of the synthetic pentadecapeptide BPC-157 (derived from a gastric protective protein), TB-500 (a synthetic fragment of thymosin beta-4), and GHK-Cu (a copper-binding tripeptide). Preclinical studies suggest that BPC-157 promotes angiogenesis and tissue protection, TB-500 facilitates actin regulation and cell migration, and GHK-Cu supports collagen synthesis and extracellular matrix remodeling. These peptides may exhibit complementary actions in models of wound healing, skin regeneration, and tissue repair.[1][2]
Key Research Areas
- Wound Healing & Skin Regeneration – In preclinical models, GHK-Cu has been shown to stimulate collagen and elastin production, enhance fibroblast activity, and promote dermal remodeling; BPC-157 accelerates epithelialization and collagen organization in injury models, while TB-500 supports cell migration and reduces excessive fibrosis.[3][4]
- Angiogenesis & Vascular Support – BPC-157 upregulates VEGF signaling in ischemic tissues, TB-500 promotes endothelial cell differentiation and vessel formation, and GHK-Cu enhances capillary growth through copper-dependent pathways in various preclinical wound models.[5][6]
- Tissue Remodeling & Anti-Inflammatory Pathways – The combination may modulate inflammatory mediators, support balanced extracellular matrix turnover, and promote antioxidant activity via complementary mechanisms in in vitro and animal studies.[1][7]
Product Specifications
| CAS Number |
BPC-157: 137525-51-0 / TB-500: 77591-33-4 / GHK-Cu: 49557-75-7 |
| Molecular Formula |
Blend (BPC-157: C62H98N16O22 / TB-500: C212H350N56O78S / GHK-Cu: C14H24CuN6O4) |
| Molar Mass |
Blend (BPC-157: 1419.56 g/mol / TB-500: 4963.50 g/mol / GHK-Cu: 403.92 g/mol) |
| Sequence |
BPC-157: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
TB-500: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser
GHK-Cu: Gly-His-Lys-Cu2+ |
| Synonyms |
BPC-157/TB-500/GHK-Cu Blend, Regeneration Blend, GLOW Blend |
| Purity |
≥99% (HPLC) |
| Form |
Lyophilized powder |
| Storage |
−20°C (long-term), 2–8°C (reconstituted) |
| Solubility |
Bacteriostatic water or saline for reconstitution |
References
- 1. Pickart L, et al. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018. PubMed
- 2. Chang CH, et al. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol. 2011. PubMed
- 3. Maquart FX, et al. Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. FEBS Lett. 1988. PubMed
- 4. Philp D, et al. Thymosin beta4 promotes angiogenesis, wound healing, and hair follicle development. Mech Ageing Dev. 2004. PubMed
- 5. Seiwerth S, et al. BPC 157 and blood vessels. Curr Pharm Des. 2014. PubMed
- 6. Smart N, et al. Thymosin beta4 accelerates wound healing. J Invest Dermatol. 2007. PubMed
- 7. Wang X, et al. GHK-Cu-liposomes accelerate scald wound healing in mice by promoting cell proliferation and angiogenesis. Wound Repair Regen. 2017. PubMed
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