GHK-Cu
GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper Complex) is a naturally occurring tripeptide-copper complex found in human plasma, saliva, and urine. Preclinical studies in cell cultures and animal models indicate that GHK-Cu promotes collagen and glycosaminoglycan synthesis, stimulates extracellular matrix remodeling, enhances wound healing, and exhibits antioxidant and anti-inflammatory properties.[1][2]
Key Research Areas
- Wound Healing & Tissue Remodeling – In vitro fibroblast cultures and animal skin wound models show GHK-Cu accelerates granulation tissue formation, increases collagen deposition, and promotes balanced matrix metalloproteinase activity for tissue repair.[3][4]
- Antioxidant & Anti-Inflammatory Effects – Preclinical investigations demonstrate GHK-Cu reduces oxidative stress, modulates inflammatory cytokine expression, and activates protective pathways (e.g., superoxide dismutase) in models of tissue injury and aging.[5][6]
- Cellular Regeneration & Gene Expression – Studies in human cell lines reveal GHK-Cu influences expression of genes related to tissue repair, angiogenesis, and extracellular matrix components, supporting regenerative processes in dermal and epithelial models.[1][7]
Product Specifications
| CAS Number |
49557-75-7 |
| Molecular Formula |
C14H24CuN6O4 |
| Molar Mass |
403.92 g/mol |
| Sequence |
Gly-His-Lys-Cu2+ |
| Synonyms |
Copper Tripeptide-1, GHK Copper, Copper Peptide GHK-Cu |
| Purity |
≥99% (HPLC) |
| Form |
Lyophilized powder (blue color due to copper) |
| Storage |
−20°C (long-term), 2–8°C (reconstituted) |
| Solubility |
Bacteriostatic water or sterile saline for reconstitution |
References
- 1. Pickart L, et al. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018. PubMed
- 2. Maquart FX, et al. Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. FEBS Lett. 1988. PubMed
- 3. Siméon A, et al. The tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ stimulates matrix metalloproteinase-2 expression by fibroblast cultures. Life Sci. 2000. PubMed
- 4. Wegrowski Y, et al. Stimulation of sulfated glycosaminoglycan synthesis by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. Life Sci. 1992. PubMed
- 5. Pickart L, et al. GHK-Cu peptide in skin regeneration and anti-aging. Biogerontology. 2015. PubMed
- 6. Wang X, et al. GHK-Cu-liposomes accelerate scald wound healing in mice by promoting cell proliferation and angiogenesis. Wound Repair Regen. 2017. PubMed
- 7. Pickart L, et al. The human tripeptide GHK and tissue remodeling. J Biomol Struct Dyn. 2004. PubMed
- 8. Pickart L, et al. GHK and DNA: resetting the human genome to health. Biomed Res Int. 2014. PubMed
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