DSIP
DSIP (Delta Sleep-Inducing Peptide) is a nonapeptide originally isolated from cerebral venous blood of rabbits during sleep induction. Preclinical studies in animal models indicate that DSIP may modulate sleep patterns, exert stress-protective effects, and influence neuroendocrine regulation. Research has explored its potential to promote delta-wave sleep and normalize disturbed sleep architecture in various experimental paradigms.[1][2]
Key Research Areas
- Sleep Regulation & Delta-Wave Promotion – In rabbit and rat models, DSIP administration has been shown to increase delta (slow-wave) sleep duration, reduce sleep latency, and normalize sleep-wake cycles in stress-induced or pharmacologically disrupted sleep patterns.[3][4]
- Stress Protection & Adaptation – Preclinical investigations demonstrate DSIP's ability to attenuate stress responses, protect against metabolic disturbances under chronic stress, and modulate HPA axis activity in animal models of immobilization or cold stress.[5][6]
- Neuroendocrine & Pain Modulation Pathways – Studies suggest DSIP influences opioid systems, reduces nociceptive responses in pain models, and affects release of hormones such as LH and GH in certain experimental conditions.[7][8]
Product Specifications
| CAS Number |
62568-57-4 |
| Molecular Formula |
C35H48N10O15 |
| Molar Mass |
848.82 g/mol |
| Sequence |
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu |
| Synonyms |
Delta Sleep-Inducing Peptide, DSIP nonapeptide |
| Purity |
≥99% (HPLC) |
| Form |
Lyophilized powder |
| Storage |
−20°C (long-term), 2–8°C (reconstituted) |
| Solubility |
Bacteriostatic water or sterile saline for reconstitution |
References
- 1. Schneider-Helmert D, et al. Delta sleep-inducing peptide (DSIP): a review. Neuropsychobiology. 1984. PubMed
- 2. Kovalzon VM, et al. Delta sleep-inducing peptide (DSIP): twenty years of research. Neurosci Behav Physiol. 2001. PubMed
- 3. Graf M, et al. Delta sleep-inducing peptide promotes slow-wave sleep in rabbits. Neurosci Lett. 1984. PubMed
- 4. Monti JM, et al. Delta sleep-inducing peptide (DSIP) and its effects on sleep in rats. Pharmacol Biochem Behav. 1987. PubMed
- 5. Khvatova EM, et al. Delta sleep-inducing peptide (DSIP) and its analogs as potential therapeutic agents. Peptides. 2003. PubMed
- 6. Schneider-Helmert D. DSIP: delta sleep-inducing peptide and its analogs. Trends Pharmacol Sci. 1985. PubMed
- 7. Graf M, et al. DSIP reduces nociceptive responses in mice. Neuropeptides. 1985. PubMed
- 8. Kovalzon VM, et al. DSIP: effects on endocrine functions in rats. Neuroendocrinol Lett. 1998. (Endocrine modulation data)
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