BPC-157
BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide derived from a protective protein found in human gastric juice. Preclinical studies in various animal models indicate that BPC-157 promotes angiogenesis, accelerates tendon and ligament healing, protects gastrointestinal mucosa, and supports tissue repair processes without apparent toxicity.[1][2]
Key Research Areas
- Tendon, Ligament & Musculoskeletal Repair – In rat models of Achilles tendon transection, muscle crush injury, and ligament damage, BPC-157 has been shown to enhance tendon outgrowth, improve collagen organization, accelerate functional recovery, and promote healing via upregulation of growth factors.[3][4]
- Gastrointestinal Protection & Healing – Preclinical investigations demonstrate BPC-157 counteracts damage from NSAIDs, alcohol, and other ulcerogens, stabilizes gastric mucosa, and accelerates healing of fistulas and intestinal lesions in animal models.[5][6]
- Angiogenesis & Vascular Function – Studies in ischemic and vascular injury models suggest BPC-157 upregulates VEGF expression, improves endothelial function, and supports new vessel formation while modulating nitric oxide pathways.[7][8]
Product Specifications
| CAS Number |
137525-51-0 |
| Molecular Formula |
C62H98N16O22 |
| Molar Mass |
1419.56 g/mol |
| Sequence |
Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val |
| Synonyms |
Body Protection Compound 157, PL 14736, Bepecin |
| Purity |
≥99% (HPLC) |
| Form |
Lyophilized powder |
| Storage |
−20°C (long-term), 2–8°C (reconstituted) |
| Solubility |
Bacteriostatic water or saline for reconstitution |
References
- 1. Sikiric P, et al. Stable gastric pentadecapeptide BPC 157 heals rat colovesical fistula. Eur J Pharmacol. 2016. PubMed
- 2. Sikiric P, et al. Gastric pentadecapeptide BPC 157 as an effective therapy for muscle crush injury in the rat. J Physiol Pharmacol. 2006. PubMed
- 3. Chang CH, et al. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol. 2011. PubMed
- 4. Staresinic M, et al. Effective therapy of transected quadriceps muscle in rat: gastric pentadecapeptide BPC 157. J Orthop Res. 2006. PubMed
- 5. Sikiric P, et al. Pentadecapeptide BPC 157 positively affects both non-steroidal anti-inflammatory agent-induced gastrointestinal lesions and brain lesions. Life Sci. 1997. PubMed
- 6. Sikiric P, et al. BPC 157 and standard healing procedure. Med Sci Monit. 2013. PubMed
- 7. Seiwerth S, et al. BPC 157 and blood vessels. Curr Pharm Des. 2014. PubMed
- 8. Vukojevic J, et al. BPC 157 as useful cytoprotective peptide therapy in the heart disturbances, myocardial infarction, heart failure, pulmonary hypertension and arrhythmias. Acta Pharmacol Sin. 2020. PubMed
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