AOD-9604
AOD-9604 is a modified C-terminal fragment of human growth hormone (hGH 177-191) with an added N-terminal tyrosine. Preclinical research explores its selective lipolytic activity and metabolic effects without the full growth-promoting actions of hGH.
Key Research Areas
- • Studied for potent lipolytic effects and stimulation of fat breakdown while inhibiting lipogenesis in adipose tissue models.
- • Investigated for reduction of body fat and improvement of metabolic parameters in obesity and weight management research.
- • Explored for potential supportive effects on cartilage repair and joint health in some preclinical models.
AOD-9604 Reconstitution Notice & Disclaimer
AOD-9604 is supplied as a lyophilized powder and requires careful reconstitution for research use. Due to its hydrophobic nature and pH-sensitive solubility, AOD-9604 tends to gel, become cloudy, or form aggregates without proper low-pH conditions.
Included with Purchase: Each order includes a 3mL vial of Acetic Acid 0.6% solution to aid reconstitution.
Recommended Reconstitution (for a standard 10mg vial):
- Allow the lyophilized AOD-9604 vial and your 0.6% acetic acid solution to reach room temperature before mixing (approximately 68–77°F). Avoid using cold (refrigerated) components directly, as temperature gradients can increase the risk of immediate gelling during dissolution.
- Use the provided 0.6% acetic acid solution to achieve full dissolution—add it slowly along the vial wall.
- Gently swirl—do not shake vigorously, as excessive agitation can promote gelling or solidification.
- For optimal results, reduced long-term viscosity issues, and better multi-dose handling, many researchers dilute further with bacteriostatic water after initial dissolution with acetic acid (common ratios: 1 part acetic acid to 2 parts bacteriostatic water, e.g., 1ml acetic acid + 2ml bacteriostatic water).
- To further mitigate the gelling issue altogether simply preload all your syringes immediately after reconstitution.
Gelling Behavior: Reconstituted AOD-9604 may naturally develop increased viscosity, cloudiness, or gel formation—even with 0.6% acetic acid—especially in high-purity batches. This is a normal characteristic of the peptide and does not indicate degradation of purity or loss of functionality. If gelling occurs, add a small additional amount of 0.6% acetic acid to restore fluidity.
No Replacements for Improper Handling: We do not replace or refund AOD-9604 due to gelling, cloudiness, aggregation, contamination, or other issues resulting from reconstitution errors, use of incorrect/non-provided solvents, excessive agitation, improper storage (including temperature mishandling), or multi-use contamination risks.
Product Specifications
| Product |
AOD-9604 |
| CAS Number |
221231-10-3 |
| Molecular Formula |
C78H123N23O23S2 |
| Molar Mass |
1815.1 g/mol |
| Sequence |
Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (disulfide bridge) |
| Synonyms |
AOD-9604; hGH Fragment 177-191; Tyr-hGH 177-191 |
| Purity |
≥99% (HPLC) |
| Form |
Lyophilized powder |
| Storage |
−20°C (−4°F) long-term; 2–8°C (36–46°F) reconstituted |
| Solubility |
Acetic Acid 0.6%; Bacteriostatic water 0.9% for laboratory use |
All products offered by Premier Research are intended for laboratory research use only. These materials are not for human or veterinary consumption, medical use, diagnostic procedures, or therapeutic applications. Statements on this website are for informational and educational purposes only and have not been evaluated by the U.S. Food and Drug Administration (FDA). By accessing this site, you confirm that you are a qualified researcher or institution representative and agree to use all materials in accordance with applicable laws, regulations, and safety guidelines.
