AHK-Cu
AHK-Cu (L-alanyl-L-histidyl-L-lysine copper complex) is a synthetic copper-bound tripeptide analog of glycyl-L-histidyl-L-lysine (GHK-Cu), designed to enhance stability and activity in certain models. Preclinical studies indicate that AHK-Cu promotes dermal papilla cell proliferation, reduces apoptosis, and stimulates hair follicle elongation ex vivo, while also supporting collagen synthesis and extracellular matrix remodeling in fibroblast cultures.[1][2]
Key Research Areas
- Hair Follicle Growth & Regeneration – Ex vivo human hair follicle models and cultured dermal papilla cells show AHK-Cu stimulates elongation, enhances proliferation, and inhibits apoptosis via modulation of Bcl-2/Bax ratios and caspase pathways.[1]
- Wound Healing & Tissue Remodeling – In vitro fibroblast studies demonstrate AHK-Cu increases collagen and glycosaminoglycan synthesis, upregulates matrix metalloproteinase expression, and promotes balanced extracellular matrix turnover.[2][3]
- Antioxidant & Anti-Inflammatory Pathways – Preclinical models suggest copper-tri peptide complexes like AHK-Cu elevate antioxidant enzyme levels and modulate inflammatory responses during tissue repair processes.[4][5]
Product Specifications
| CAS Number |
682809-25-0 |
| Molecular Formula |
C17H29CuN7O5 |
| Molar Mass |
474.00 g/mol (approximate, complex) |
| Sequence |
Ala-His-Lys-Cu2+ |
| Synonyms |
Alanyl-histidyl-lysine copper, AHK copper peptide |
| Purity |
≥99% (HPLC) |
| Form |
Lyophilized powder |
| Storage |
−20°C (long-term) |
| Solubility |
Water-soluble; acetic acid or saline for reconstitution |
References
- 1. Pyo HK, et al. The effect of tripeptide-copper complex on human hair growth in vitro. Arch Pharm Res. 2007. PubMed
- 2. Maquart FX, et al. Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. FEBS Lett. 1988. PubMed
- 3. Siméon A, et al. The tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ stimulates matrix metalloproteinase-2 expression by fibroblast cultures. Life Sci. 2000. PubMed
- 4. Pickart L, et al. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018. PubMed
- 5. Wegrowski Y, et al. Stimulation of sulfated glycosaminoglycan synthesis by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. Life Sci. 1992. PubMed
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